ZW10 interactor is also known as Zwint-1 and ZWINT. It is located to kinetochores from late prophase to anaphase and has a uniform distribution in the cytoplasm of interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.

·Description
Novoprotein Recombinant Human ZWINT produced by e.coli expression system.Target protein is expressed with sequence (Met1-Pro277) of Human (Uniprot #O95229) fused with a His tag at the C-terminus.

·Quality Control

Purity: Greater than 90.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
 

Endotoxin:Less than 0.1ng/μg (1EU/μg) of ZWINT (Human)

Please avoid freeze-thaw cycles.