Recombinant Human Pro-Brain-Derived Neurotrophic Factor/pro-BDNF (C077)

目录 规格 价格
【BDNF(with pro peptide)产品说明】:
Recombinant Human pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247 is expressed.
【BDNF(with pro peptide)质量控制】:
Greater than 95% as determined by reducing SDS-PAGE.
【BDNF(with pro peptide)制剂】:
Lyophilized
【BDNF(with pro peptide)保存】:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
【BDNF(with pro peptide)复溶】:
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
【关于BDNF(with pro peptide)】:
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
参考文献

  • Sánchez E, Bergareche A, Krebs C E.
    SORT1 mutation resulting in sortilin deficiency and p75NTR upregulation in a family with essential tremor.
    ASN neuro(2015)
For research use ONLY.