Recombinant Human Interleukin-16/IL-16 (C045)

目录 规格 价格
【IL-16产品说明】:
Recombinant Human Interleukin-16 is produced by our E.coli expression system and the target gene encoding Met1-Ser130 is expressed.
【IL-16质量控制】:
Measured by its to chemoattract human CD4+ T-lymphocytes using a concentration range of 10.0-100.0 ng/ml
Specific Activity is greater than 1.0 x 10^4 IU/mg.
Greater than 95% as determined by reducing SDS-PAGE.
【IL-16制剂】:
Lyophilized
【IL-16保存】:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
【IL-16复溶】:
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
【关于IL-16】:
Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
参考文献

  • Marong Fang, Yayi Sun, Zhiying Hu, Jing Yang , Henry Davies , Beibei Wang , Shucai Ling , Shu Han .
    C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model.
    Neuropharmacology(2013)
For research use ONLY.