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Recombinant Human Interleukin-17A/IL-17A (C021)

目录 规格 价格
【IL-17/IL-17A产品说明】:
Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Ile20-Ala155 is expressed.
【IL-17/IL-17A质量控制】:
Measured by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts.
ED50 is approximately 2 ng/ml. Specific Activity of 5 x 10^5 IU/mg.
Greater than 95% as determined by reducing SDS-PAGE.
【IL-17/IL-17A制剂】:
Lyophilized
【IL-17/IL-17A保存】:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
【IL-17/IL-17A复溶】:
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
【关于IL-17/IL-17A】:
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
For research use ONLY.