Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3 (C033)

目录 规格 价格
【IL-1F3/IL-1Ra产品说明】:
Recombinant Human Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg26-Glu177 is expressed.
【IL-1F3/IL-1Ra质量控制】:
Measured by the dose-dependent inhibition of IL-1 stimulation of D10S cells.
ED50 is 0.5 ng/ml. Specific Activity of 2.0 x 10^6 IU/mg.
Greater than 95% as determined by reducing SDS-PAGE.
【IL-1F3/IL-1Ra制剂】:
Lyophilized
【IL-1F3/IL-1Ra保存】:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
【IL-1F3/IL-1Ra复溶】:
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
【关于IL-1F3/IL-1Ra】:
Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.
For research use ONLY.