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Recombinant Human Guanidinoacetate N-Methyltransferase/GAMT (N, C-6His) (CG67)

目录 规格 价格
【GAMT产品说明】:
Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
【GAMT质量控制】:
Greater than 95% as determined by reducing SDS-PAGE.
【GAMT制剂】:
Liquid
【GAMT保存】:
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
【关于GAMT】:
GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.
For research use ONLY.