Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E.coli) (C011)

目录 规格 价格
【CD40 Ligand/TNFSF5产品说明】:
Recombinant Human CD40 Ligand is produced by our E.coli expression system and the target gene encoding Met113-Leu261 is expressed.
【CD40 Ligand/TNFSF5质量控制】:
Measured by the dose-dependent stimulation of IL-12 & IL-8 induction by PMB cells.
ED50 is 5-10 ng/ml.
Greater than 95% as determined by reducing SDS-PAGE.
【CD40 Ligand/TNFSF5制剂】:
【CD40 Ligand/TNFSF5保存】:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
【CD40 Ligand/TNFSF5复溶】:
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
【关于CD40 Ligand/TNFSF5】:
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.

  • Piec I, Tang J, Washbourne C, et al.
    Measurement of autoantibodies against osteoprotegerin in adult human serum: development of a novel ELISA assay.
    American Society of Bone and Mineral Research(2014)
For research use ONLY.