精氨酸甲基转移酶2(PRMT2) (MC875)

目录 规格 价格
功能
精氨酸甲基转移酶可以甲基化蛋白质精氨酸残基上的胍基氮,靶蛋白包括STAT3, FBL, 组蛋白H4等。
催化反应
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
动力学常数
KM=2.6 µM for AdoMet
KM=3.3 µM for H4
Vmax=1.4 nmol/min/mg enzyme toward AdoMet
Vmax=1.5 nmol/min/mg enzyme toward H4
参考文献
Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4.
Lakowski T.M., Frankel A. Biochem. J. 421:253-261(2009)
For research use ONLY.